The Rapid Deployment Vaccine Collaborative (Radvac) is a 501(c)(3) nonprofit organization formed to enable rapid production and deployment of safe and effective pathogen countermeasures (including low-cost vaccines; rapidly configurable antiviral therapies; broad-spectrum antiviral prophylactics; and the production capacity for each) in the earliest days of outbreaks. We create proof-of-principle demonstrations of early stage countermeasures, and freely share methods and protocols for decentralized production and deployment.
We believe that the foundation of effective countermeasures is maximal access in terms of both speed and geography, including and especially in low-resource areas. Two key ways we aim to fulfill the promise of maximal access is through self-production and self-administration of biosecurity tools.
Beginning in March 2020, in less than one month, we designed, produced, and self-administered the first of several progressive generations of nasal vaccines against SARS-CoV-2, and we shared all methods and protocols online in a series of white papers. We chose not to file patents or secured other intellectual property protections, and all information on our vaccine designs, production, self-administration, and testing has been freely shared on this website under open licenses (CC BY 4.0 and OCL-P v1.1) in partnership with the Creative Commons Open COVID Pledge. To coordinate research efforts, we have established a collaborative network via our Researchers Map, and other outreach activities.





Nasal SARS-CoV-2 peptide vaccine
Our protocol for a peptide-conjugate intranasal vaccine, optimized across five revisions for breadth and durability against emerging SARS-CoV-2 variants.
Modernized variolation
Protocols for collecting mucus samples, inactivating viruses, and administering variolation safely. Additional protocols for decentralized sample collection and sharing.
Vaccine factories in a tube
Protocols for using genetically-modified yeast to generate vaccine factories in a tube. Vaccines can be delivered orally, nasally, or both.
AI for rapid drug repurposing and antiviral combinations design
Leveraging advances in open source data and AI to repurpose existing drugs and GRAS compounds as antivirals. New techniques for combining several weak antivirals into powerful combinations.
Radvac is building the open infrastructure required to respond to biological threats in hours or days, not months or years.